Team Reshade released a brand new version available for download. According to the team, Reshade 5.0 is a major redesign of the underlying architecture to improve performance, simplify maintenance, and add features in the future. In addition, it comes with a new extremely powerful additional API.
Reshade 5.0 improves performance by automatically disabling GPU statistics collection when the statistics window is not displayed. Performance is also improved by using a multi-threaded call to the HLSL compiler during effect compilation. The new version also improves performance in OpenGL with better management of thread local storage.
You can download Reshade 5.0 from here.